Central imaging review
Central imaging review (CIR) plays a critical role in clinical trials where imaging data defines key endpoints. Consistency, accuracy and control are essential to ensure that results are reliable and accepted by regulatory authorities.
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- Central imaging review
Central imaging review that ensures consistent endpoints and regulatory confidence
At DICE, we support central imaging review across the full study lifecycle, from setup to final analysis. With expertise in radiology and nuclear medicine, we ensure that imaging processes are clearly defined, consistently executed and fully aligned with regulatory expectations. Our approach applies to all studies involving DICOM imaging data, including CT, MRI and PET.
Imaging charter and SOP development
Development of imaging charters and CIR-specific SOPs that define processes clearly from study start through to database lock.
Imaging site selection and setup
Definition of site selection criteria, including scanner requirements and qualification of site personnel.
Imaging procedures manual
Preparation of study-specific manuals to ensure consistent execution across all imaging sites.
Blinded independent central review (BICR)
Execution of blinded central reading processes to ensure unbiased and consistent image evaluation.
Quantitative and qualitative image analysis
Application of validated criteria such as RECIST, iRECIST, PERCIST, EORTC and Choi to ensure standardized endpoint assessment.
Data management for imaging trials
Management of imaging data with a focus on consistency, traceability and alignment with study requirements.
Endpoint definition and validation
Support in defining and validating imaging endpoints in line with regulatory expectations.
Common challenges we help to prevent
• Variability in image acquisition and interpretation across sites
• Inconsistent application of imaging criteria
• Delays in image review and endpoint validation
• Misalignment with regulatory expectations for imaging endpoints
The result
You get a consistent and well-controlled imaging review process that supports reliable endpoint evaluation and strengthens regulatory confidence.
How we work
We take a structured and study-specific approach, ensuring that imaging processes are clearly defined, consistently applied and fully documented. This enables efficient execution and dependable outcomes across your trial.
Would you like to start a project with us?
Or call us: +32 2 465 76 50
"Amazing Designs and Quality Work!"
